Three Cases of Familial Papillary Carcinoma of Thyroid in a Family and its Management in Rural Hospital

Papillary thyroid cancer (PTC) is one of the most common thyroid malignancies, with an increase in incidence rates over the past few decades. The exact cause of thyroid cancer in most patients is still unclear but the possibility of genetic predisposition to PTC cannot be overlooked. The literature review on familial papillary thyroid carcinoma was done. Its occurrence at an advanced stage in closely related individuals in early life, suggests that underlying genetic factors may predispose this malignancy. We had speculated that some gene-related factor might play an important role in familial occurrence PTC. This report describes three sisters of first degree relation with papillary thyroid carcinoma.